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Anticancer  & Chemoprevention Activity Tests

Cytostatic assays

Cytotoxicity assays

Cell proliferation assays

Apoptosis measurements

Immunomodulatory effects

In vitro angiogenesis study models

In vitro models of cancer metastasis

Cellular/molecular mechanism of actions


 Please refer to the following papers for exemplary work on these topics:

  • Nabavi, S.F., Khan, H., D'onofrio, G., Šamec, D.,  Shirooie, S.,  Dehpour, A.R., Castilla, S.A.,  HABTEMARIAM, S.,   Sobarzo-Sanchez, E. (2017). Apigenin as Neuroprotective Agent: Of mice and men. Pharmacological Research. In Press. Abstract

  • HABTEMARIAM, S. (2017). Methodology for rapid isolation of moringin: potential anticancer compound from the seeds of Moringa stenopetala. Pharmaceutica Analytica Acta 8(8), 558.  Full Text

  • Gualdani, R., Cavalluzzi, M.M., Lentini, G., HABTEMARIAM, S. (2016). The chemistry and pharmacology of citrus limonoids. Molecules 21(11), 1530. Invited review article (38 pages). Free Full Text Article or PDF

  • Devi K.P., Rajavel T., HABTEMARIAM S., Nabavi S.F., Nabavi S.M. Molecular mechanisms underlying the anticancer effects of myricetin. Life Sciences 142, 19-25. Abstract 

  • Spagnuolo, C., Russo, G.U., Orhan, I.E., HABTEMARIAM, S., Daglia, M., Sureda, A., Nabavi, S.F., Devi, K.P., Loizzo, R.M., Tundis R., Nabavi, S.M. (2015). Genistein and cancer: current status, challenges, and future direction. Advances in Nutrition  6(4), 408-419. Abstract

  • Nabavi, S.M., HABTEMARIAM, S., Daglia, M., Nabavi, S.F. (2015). Apigenin and breast cancers: From chemistry to medicine. Anti-Cancer Agents in Medicinal Chemistry 15(6), 728-35. Abstract

  • HABTEMARIAM, S., Varghese, G.K. (2015). A Novel Diterpene Skeleton: Identification of a highly aromatic, cytotoxic and antioxidant 5-methyl-10-demethyl-abietane-type diterpene from Premna serratifolia. Phytotherapy Research 29(1), 80-85.  Abstract

  • Civenni, G., Iodice, M.G., Nabavi, S.F., HABTEMARIAM, S., Nabavi, S.M., Catapano, C.V., Dagli M.G. (2015). Gallic acid and methyl-3-O-methyl gallate: a comparative study on their effects on prostate cancer stem cells. RSC Advances  5, 63800–63806. Abstract

  • Nabavi, S.F., Bilotto, S., Russo, G.L., Orhan, I.E, HABTEMARIAM, S., Daglia,  M., Devi, K.P., Loizzo, M.R., Tundis, R., Nabavi, S.M. (2015).  Omega-3 polyunsaturated fatty acids and cancers: Lessons learnt from clinical trials. Cancer & Metastasis Reviews 34(3), 359-380. Abstract

  • HABTEMARIAM, S. (2010). Knipholone anthrone from Kniphofia foliosa induces a rapid onset of necrotic cell death in cancer cells. Fitoterapia. 81(8), 10131019

  • HABTEMARIAM S. and Dagne E. (2010). Comparative antioxidant, prooxidant and cytotoxic activity of sigmoidin A and eriodictyol. Planta Med. 76(6), 589594. Abstract

  • Deshmukh, S.R.,  HABTEMARIAM,  S., Wadegaonkar, P.A. (2010). Antioxidant and antiproliferative activity of root suspension culture of Morinda citrifolia L. Research Journal of Pharmacy & Technology 3(4), 1189-1193. Abstract

  • Sánchez-Medina, Peña-Rodríguezb  L.M., May-Pat  F., Karagianisd G., Waterman P.G. , Mallet A.I.  and  HABTEMARIAM S* (2010). Identification of Sakurasosaponin as a Cytotoxic Principle from Jacquinia flammea. Natural Product Communications 5(3), 365-368.  Abstract

  • Sánchez-Medina, A.,  Stevenson, P.C., HABTEMARIAM, S.,  Peña-Rodríguez, L.M., Corcoran, O., Mallet, A.I.,  Veitch N.C. (2009). Triterpenoid saponins from a cytotoxic root extract of Sideroxylon foetidissimum subsp. gaumeri. Phytochemistry 70(6), 765–772. Abstract

  • HABTEMARIAM, S. (2003). Cytotoxic and cytostatic activity of erlangerins from Commiphora erlangeriana. Toxicon, 41, 723-727. Abstract

  • HABTEMARIAM, S. (2000). Natural inhibitors tumour necrosis factor-a production, secretion and function. Review article. Planta Med. 66, 303-313.

  • HABTEMARIAM, S., Skelton, B.W., Waterman, P.G. and White, A.  (2000). 17-Epi-acnistin-A, a further withanolide from the leaves of Discopodium penninervium.  J. Nat. Prod. 63, 512-513.

  • HABTEMARIAM, S., MacPherson, A.M. (2000). Cytotoxicity and antibacterial activity of ethanolic axtract from leaves of a herbal drug, Boneset (Eupatorium perfoliatum). Phytotherapy Res. 14, 575-577.

  • HABTEMARIAM, S. and Gray, A.I. (1998). Withanolides from the roots of Discopodium penninervium. Planta Med. 64, 275-276.

  • HABTEMARIAM, S. (1997). Flavonoids as inhibitors or enhancers of the cytotoxicity of tumor necrosis factor-alpha in L-929 tumor cells.. J. Nat Prod. 60, 775-778.

  • Habtemariam, S. (1997). Modulation of tumour necrosis factor-a-induced cytotoxicity  by polyphenols Phytother. Res. 11(4), 277-80. Article

  • Habtemariam S. (1997).  Cytotoxicity and immunosuppressive activity of withanolides from Discopodium penninervium. Planta Med., 63, 15-17.

  • Habtemariam S. (1996). Cytotoxicity of extracts from the mushroom Paxillus involutus. Toxicon 34, 711-713.

  •  Habtemariam, S. (1995). Cytotoxicity of diterpenes from Premna schimperi and Premna oligotricha. Planta Med. 61, 368-369.

.... and  our publications' page for more references.


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The Site Owner

Dr Habtemariam BSc, MSc, PhD........FRSM, FRSC. .... With a Principal Lecturer post at Greenwich, Dr Habtemariam is a leader of the BSc Pharmaceutical Science programme and researches on bioassay & natural products-based drug development. ....More



In addition to our fully equipped tissue culture facilities, we have  access to various state-of-the-art equipment including ICP-MS, LC-MS, MALDI-TOF-MS, FABS-MS, FTIR, Laser-Raman,  scanning  and transmission  electron microscopes, flow cytometer, NMR (270, 300 and 500MHz),  automated DNA sequencers, various HPLC systems,  capillary electrophersis and ABI PRCmate DNA synthetisers.










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